Metabolite Profiling (GC-MS), Antioxidant and Antimicrobial Activities of Baccharis dracunculifolia Hydroalcoholic Extract
DOI:
https://doi.org/10.17921/1415-6938.2026v30n1p23-36Resumo
Baccharis dracunculifolia, popularmente conhecida como "alecrim do campo", é um arbusto nativo da América do Sul que apresenta propriedades anti-inflamatórias, antimicrobianas, anticancerígenas e antioxidantes. Contudo, ainda são escassos os estudos que relacionam sua composição química às atividades biológicas. Este estudo avaliou o perfil metabólico do extrato hidroalcoólico de B. dracunculifolia por cromatografia gasosa acoplada à espectrometria de massas (CG-EM) e determinar sua atividade antioxidante e antibacteriana. Foram identificados 16 metabólitos, predominantemente terpenoides (46%), além de cetonas, aldeídos, hidrocarbonetos e ácidos. O extrato apresentou atividade antioxidante com CI50 de 17,7 ± 0,02 mg/mL (ensaio DPPH) e 361 ± 0,03 µmol Trolox/g (ensaio ABTS). O teor total de flavonoides foi de 6,0 ± 0,14 mg de rutina/100 g de extrato (p/p) e o de fenóis totais de 17,10 ± 0,27 mg GAE/g. Em relação à atividade antimicrobiana, o extrato apresentou efeito bacteriostático (CIM) variando de 370 µg/mL para L. monocytogenes a 7500 µg/mL para P. aeruginosa, e efeito bactericida (CBM) entre 2500 µg/mL para S. aureus e 30000 µg/mL para E. coli. O potencial bioativo observado pode ser atribuído, em grande parte, à presença de triterpenos. Assim, o extrato de B. dracunculifolia configura-se como uma fonte relevante para investigações farmacológicos, fitoquímicas e microbiológicas.
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Copyright (c) 2026 Alexsandra Iarlen Cabral Cruz, Milena da Cruz Costa, Jessica Ferreira Mafra, Mariza Alves Ferreira, Alana Kercia Marques Miranda, Paulo Roberto Ribeiro, Floricéa Magalhães Araújo, Norma Suely Evangelista-Barreto
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