Os Efeitos do Jejum Intermitente nos Parâmetros Bioquímicos de Ratos Wistar
DOI:
https://doi.org/10.17921/1415-6938.2019v23n3p238-243Resumo
O presente estudo teve como objetivo avaliar as repercussões bioquímicas em ratos Wistar submetidos ao jejum intermitente por 15, 30 e 60 dias, modelo de dieta intercalada por períodos de restrição total de alimentação com períodos de alimentação ad libitum. O estudo foi realizado com 40 ratos Wistar, machos divididos em três grupos, todos recebendo a ração Nuvital®. Os ratos submetidos ao jejum intermitente tiveram esse tipo de dieta durante 3 dias na semana e nos demais dias tiveram acesso livre a ração e água. Os animais foram pesados semanalmente e, após o período de jejum intermitente, foram eutanasiados para a coleta de sangue e análise bioquímica (glicemia, triglicérides, colesterol total e frações). Houve redução significativa do peso e triglicerídeos nos animais do grupo de jejum em relação ao grupo controle durante 15 dias. Em relação ao grupo de 30 dias de jejum, houve redução significativa de colesterol total e HDL. Nos animais submetidos à dieta durante 60 dias, houve diminuição significativa de colesterol total e HDL, no entanto, o consumo de água aumentou consideravelmente. Conclui-se que o jejum intermitente durante 15 dias causou alterações bioquímicas favoráveis ao metabolismo desses animais.
Palavras-chave: Jejum Intermitente. Restrição Calórica. Prevenção.
Abstract
This experiment was conducted to evaluate the biochemical effects in healthy Wistar rats submitted by 15, 30 and 60 days to intermittent fasting, a model of interspersed diet between periods of total food restriction withfood ad libitum period. The study was performed with 40 male Wistar rats randomly divided into 3 groups, all receiving Nuvital®. The rats submitted to intermittent fasting had this type of diet during 3 days a week and on the other days had free access to food. They received water ad libitum every day. The analysis related to metabolic changes resulting from fasting were performed by means of serum biochemical analysis (blood glucose, triglycerides, total cholesterol and HDL) at the end of the experiment. There was a significant reduction of weight and triglycerides from the fasting group in relation to the control group in 15 days, there was no significant increase in parameters during this period of diet. Concerning the 30-day fasting group, there was a significant reduction of total cholesterol and HDL. Therefore, Intermittent Fasting in 15 days only demonstrated biochemical benefits.
Keywords: Intermittent Fasting. Caloric restriction. Prevention.
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